WELCOME TO THE MOSES LAB
We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.LATEST LAB NEWS
| 9 Apr. 2018 | Congratulations to Clarissa for winning the F. Michael Barrett Award at the 2017-2018 poster session! |
| 5 Apr. 2018 | Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife! |
| 2 Apr. 2017 | Our paper on non-adaptive parallel evolution is out at PLoS Genetics. |
| 2 Feb. 2017 | Taraneh's disordered protein evolution paper is published in PNAS. |
| 5 Jan. 2017 | Lab retreats to the ravines. |
CRZ1 Pulse - From Ian's research project
RECENT PUBLICATIONS
| Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM. Integrating images from multiple microscopy screens reveals diverse patterns of protein subcellular localization change. eLife 2018;7:e31872. eLife Link Article Saccharomyces cerevisiae Image analysis Subcellular localization Microscopy screens |
| Nguyen Ba AN, Strome B, Osman S, Legere EA, Zarin T, Moses AM. Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PLoS Genetics 2017 Apr 14;13(4). PLoS Genetics Link PDF Mirror PubMed Abstract Article Saccharomyces cerevisiae Evolutionary genetics Molecular evolution Natural selection Gene duplication Fungal evolution Green fluorescent protein Sequence motif analysis |
| Zarin T, Tsai CN, Nguyen Ba AN, Moses AM. Selection maintains signaling function of a highly diverged intrinsically disordered region. PNAS 2017 Feb 21;114(8). PNAS Link PDF Mirror PubMed Abstract Article Evolution Intrinsically disordered Quantitative trait Phylogenetic comparative method Stabilizing selection |
CONTACT US
The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Earth Sciences Centre (25 Willcocks St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.
