Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Research
Evolution & Dynamics
of Regulatory Networks
Research
Molecular Evolution
Of Disordered Regions
Research
Genomics & Proteomics
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Moseslab website

We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.

LATEST LAB NEWS

 

Apr. 2021congratulations to Dr. Alex for defending his PhD !
Apr. 2021Gurdeep's enhancer paper is out in Genome Research and Ian's enhancer art out on insta.
Feb. 2021Ian's review is out in the FEBS journal. Looks a this wild graphic Ian made:
I think it represents scientific attempts measure single cell variability!
Dec. 2020Check out Amy's other MLCB paper. It's become a lab mantra: Evolution is all you need.

CRZ1 Pulse - From Ian's research project

RECENT PUBLICATIONS

Zarin T, Strome B, Peng G, Pritišanac I, Forman-Kay JD, Moses AM.
Identifying molecular features that are associated with biological function of intrinsically disordered protein regions.
Elife. 2021 Feb 22;10:e60220
Elife Link PDF Mirror PubMed Abstract Article
Sequence analysis Saccharomyces cerevisiae Intrinsically disordered Evolution
Hsu IS, Moses AM Stochastic models for single-cell data: Current challenges and the way forward. FEBS J. Feb 11 2021
FEBS J. Link PDF Mirror PubMed AbstractReview
Regulatory networks Computational modeling Molecular Biology Gene Expression
Tsang B, Pritišanac I, Scherer SW, Moses AM, Forman-Kay JD Phase separation as a missing mechanism for interpretation of disease mutations Cell 2020 Dec 23
Cell Press Link PDF Mirror PubMed AbstractReview
Disease mutations Intrinsically disordered regions Phase separation Protein Condensation

CONTACT US

The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Ramsay-Wright Labs (25 Harbord St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.