We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.
LATEST LAB NEWS
|9 Apr. 2018||Congratulations to Clarissa for winning the F. Michael Barrett Award at the 2017-2018 poster session!|
|5 Apr. 2018||Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife!|
|2 Apr. 2017||Our paper on non-adaptive parallel evolution is out at PLoS Genetics.|
|2 Feb. 2017||Taraneh's disordered protein evolution paper is published in PNAS.|
|5 Jan. 2017||Lab retreats to the ravines.|
CRZ1 Pulse - From Ian's research project
|Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM. Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. eLife 2018;7:e31872.
eLife Link PDF Mirror PubMed AbstractArticle
|Liku ME, Legere EA, Moses AM NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals. BMC Bioinformatics. 2018 7:Feb 27;19(1):65.
BMC bioinformatics Link PDF Mirror PubMed AbstractArticle
|Nguyen Ba AN, Strome B, Osman S, Legere EA, Zarin T, Moses AM. Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PLoS Genetics 2017 Apr 14;13(4).
PLoS Genetics Link PDF Mirror PubMed Abstract Article