Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Research
Evolution & Dynamics
of Regulatory Networks
Research
Molecular Evolution
Of Disordered Regions
Research
Genomics & Proteomics
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Research
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WELCOME TO THE MOSES LAB

We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.

LATEST LAB NEWS

 
2 Apr. 2017Our paper on non-adaptive parallel evolution is out at PLoS Genetics.
2 Feb. 2017Taraneh's disordered protein evolution paper is published in PNAS.
5 Jan. 2017Lab retreats to the ravines.

CRZ1 Pulse - From Ian's research project

RECENT PUBLICATIONS

Nguyen Ba AN, Strome B, Osman S, Legere EA, Zarin T, Moses AM. Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PLoS Genetics 2017 Apr 14;13(4).
PLoS Genetics Link PDF Mirror PubMed Abstract Article
Saccharomyces cerevisiae Evolutionary genetics Molecular evolution Natural selection Gene duplication Fungal evolution Green fluorescent protein Sequence motif analysis
Zarin T, Tsai CN, Nguyen Ba AN, Moses AM. Selection maintains signaling function of a highly diverged intrinsically disordered region. PNAS 2017 Feb 21;114(8).
PNAS Link PDF Mirror PubMed Abstract Article
Evolution Intrinsically disordered Quantitative trait Phylogenetic comparative method Stabilizing selection
Youn JY, Friesen H, Nguyen Ba AN, Liang W, Messier V, Cox MJ, Moses AM, Andrews B. Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. G3 2017 Mar 10;7(3):911-921.
G3 Link PDF Mirror PubMed Abstract Article
Yeast genetics Genetic interactions Kinase Transcription factor Genetic networks

CONTACT US

The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Earth Sciences Centre (25 Willcocks St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.