Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Evolution & Dynamics
of Regulatory Networks
Molecular Evolution
Of Disordered Regions
Genomics & Proteomics
We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.


13 Feb. 2019Tahmid's new clustering method is out in bioinformatics. Software is here
21 Dec. 2018Check out Ian's calcium bursts, now published in G3
6 Sept. 2018Congratulations to Purnima for successfully defending her PhD thesis!
4 Jul. 2018Check out our latest paper in BMC Systems Biology
9 Apr. 2018Congratulations to Clarissa for winning the award for best poster
5 Apr. 2018Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife!

CRZ1 Pulse - From Ian's research project


Mehdi TF, Singh G, Mitchell JA, Moses AM. Variational Infinite Heterogeneous Mixture Model for Semi-supervised Clustering of Heart Enhancers. Bioinformatics 2019 Feb 7
Bioinformatics link PDF Mirror PubMed Abstract Article
Regulatory networks Transcription factors Genomics Machine Learning
Hsu IS, Strome B, Plotnikov S, Moses AM. A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast. G3 2019 Feb 7;9(2):561-570.
G3 link PDF Mirror PubMed Abstract Article
Regulatory networks Subcellular localization Time lapse microscopy Cell signaling
Lu AX, Handfield LF, Moses AM. Extracting and Integrating Protein Localization Changes from Multiple Image Screens of Yeast Cells. Bio-protocol Vol 8, Iss 18, Sep 20, 2018.
Bio-protocol link PDF Mirror
Image analysis Subcellular localization Microscopy screens


The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Earth Sciences Centre (25 Willcocks St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.