We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.
LATEST LAB NEWS
|6 Sept. 2018||Congratulations to Purnima for successfully defending her PhD thesis!|
|4 Jul. 2018||Check our latest paper in BMC Systems Biology|
|9 Apr. 2018||Congratulations to Clarissa for winning the award for best poster|
|5 Apr. 2018||Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife!|
|2 Apr. 2017||Our paper on non-adaptive parallel evolution is out at PLoS Genetics.|
|2 Feb. 2017||Taraneh's disordered protein evolution paper is published in PNAS.|
CRZ1 Pulse - From Ian's research project
|Lu AX, Handfield LF, Moses AM. Extracting and Integrating Protein Localization Changes from Multiple Image Screens of Yeast Cells. Bio-protocol Vol 8, Iss 18, Sep 20, 2018.
Bio-protocol link PDF Mirror
|Strome B, Hsu IS, Li Cheong Man M, Zarin T, Nguyen Ba A, Moses AM. Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity. BMC Syst Biol. 2018 Jul 3;12(1):75.
BMC Systems Biology Link PubMed AbstractArticle
|Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM. Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. eLife 2018;7:e31872.
eLife Link PDF Mirror PubMed AbstractArticle