Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Evolution & Dynamics
of Regulatory Networks
Molecular Evolution
Of Disordered Regions
Genomics & Proteomics
We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.


6 Sept. 2018Congratulations to Purnima for successfully defending her PhD thesis!
4 Jul. 2018Check our latest paper in BMC Systems Biology
9 Apr. 2018Congratulations to Clarissa for winning the award for best poster
5 Apr. 2018Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife!
2 Apr. 2017Our paper on non-adaptive parallel evolution is out at PLoS Genetics.
2 Feb. 2017Taraneh's disordered protein evolution paper is published in PNAS.

CRZ1 Pulse - From Ian's research project


Lu AX, Handfield LF, Moses AM. Extracting and Integrating Protein Localization Changes from Multiple Image Screens of Yeast Cells. Bio-protocol Vol 8, Iss 18, Sep 20, 2018.
Bio-protocol link PDF Mirror
Image analysis Subcellular localization Microscopy screens
Strome B, Hsu IS, Li Cheong Man M, Zarin T, Nguyen Ba A, Moses AM. Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity. BMC Syst Biol. 2018 Jul 3;12(1):75.
BMC Systems Biology Link PubMed AbstractArticle
Cell signaling Saccharomyces cerevisiae Mitogen-activated kinases Intrinsically disordered regions Short linear motifs High osmotic glycerol pathway
Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM. Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. eLife 2018;7:e31872.
eLife Link PDF Mirror PubMed AbstractArticle
Saccharomyces cerevisiae Image analysis Subcellular localization Microscopy screens


The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Earth Sciences Centre (25 Willcocks St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.