Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Evolution & Dynamics
of Regulatory Networks
Molecular Evolution
Of Disordered Regions
Genomics & Proteomics
We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.


4 Jul. 2018Check our latest paper in BMC Systems Biology
9 Apr. 2018Congratulations to Clarissa for winning the award for best poster
5 Apr. 2018Alex's paper on a systematic study of protein localization patterns using microscopy images is published in eLife!
2 Apr. 2017Our paper on non-adaptive parallel evolution is out at PLoS Genetics.
2 Feb. 2017Taraneh's disordered protein evolution paper is published in PNAS.
5 Jan. 2017Lab retreats to the ravines.

CRZ1 Pulse - From Ian's research project


Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM. Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. eLife 2018;7:e31872.
eLife Link PDF Mirror PubMed AbstractArticle
Saccharomyces cerevisiae Image analysis Subcellular localization Microscopy screens
Liku ME, Legere EA, Moses AM NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals. BMC Bioinformatics. 2018 7:Feb 27;19(1):65.
BMC bioinformatics Link PDF Mirror PubMed AbstractArticle
Saccharomyces cerevisiae Subcellular localization Sequence motif analysis
Nguyen Ba AN, Strome B, Osman S, Legere EA, Zarin T, Moses AM. Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PLoS Genetics 2017 Apr 14;13(4).
PLoS Genetics Link PDF Mirror PubMed Abstract Article
Saccharomyces cerevisiae Evolutionary genetics Molecular evolution Natural selection Gene duplication Fungal evolution Green fluorescent protein Sequence motif analysis


The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Earth Sciences Centre (25 Willcocks St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.