WELCOME TO THE MOSES LABWe are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.
CRZ1 Pulse - From Ian's research project
|Nguyen Ba AN, Strome B, Osman S, Legere EA, Zarin T, Moses AM. Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PLoS Genetics 2017 Apr 14;13(4).
PLoS Genetics Link PDF Mirror PubMed Abstract Article
|Zarin T, Tsai CN, Nguyen Ba AN, Moses AM. Selection maintains signaling function of a highly diverged intrinsically disordered region. PNAS 2017 Feb 21;114(8).
PNAS Link PDF Mirror PubMed Abstract Article
|Youn JY, Friesen H, Nguyen Ba AN, Liang W, Messier V, Cox MJ, Moses AM, Andrews B. Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. G3 2017 Mar 10;7(3):911-921.
G3 Link PDF Mirror PubMed Abstract Article