We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.
CRZ1 Pulse - From Ian's research project
|Singh G, Mullany S, Moorthy SD, Zhang R, Mehdi T, Tian R, Duncan AG, Moses AM, Mitchell JA.
A flexible repertoire of transcription factor binding sites and a diversity threshold determines enhancer activity in embryonic stem cells Genome Res. 2021 Apr;31(4):564-575
Genome Research Link PDF Mirror PubMed Abstract Article
|Zarin T, Strome B, Peng G, Pritišanac I, Forman-Kay JD, Moses AM.
Identifying molecular features that are associated with biological function of intrinsically disordered protein regions. Elife. 2021 Feb 22;10:e60220
Elife Link PDF Mirror PubMed Abstract Article
|Hsu IS, Moses AM Stochastic models for single-cell data: Current challenges and the way forward. FEBS J. Feb 11 2021
FEBS J. Link PDF Mirror PubMed AbstractReview
The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Ramsay-Wright Labs (25 Harbord St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.