Alan Moses

Computational Biology Laboratory

Computational Biology Laboratory

Computational Biology Laboratory

Evolution & Dynamics
of Regulatory Networks
Molecular Evolution
Of Disordered Regions
Genomics & Proteomics
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Moseslab website

We are a group of computational, systems, and evolutionary biologists broadly interested in molecular evolution, population genetics, and the dynamics and evolution of gene regulatory networks. Our approach is both theoretical and experimental and we try to tackle the big questions in these fields by building on the latest advances in computer science and systems biology.



07 Nov. 2019Two papers from Alex: self-supervised multiple-instance learning by Paired-Cell Inpainting and the Cells Out of Sample (COOS) dataset.
17 July 2019New work from our lab on intrinsically disordered proteins is published: information theory and evolutionary signatures
10 July 2019Congratulations to Taraneh for successfully defending her PhD thesis!
21 Jun. 2019Catch up with us on the Moses Lab summer tour 2019: Alex & Amy @ICML in USA, Ian @Quantitative Biology in China, Taraneh @yeast meeting in Sweden
1 Jun. 2019Alex's website for finding yeast cells in images is in bioinformatics. Find out more here
15 May 2019Moses Lab Retreat - a new beginning. More here

CRZ1 Pulse – From Ian’s research project


Lu AX, Lu AX, Schormann W, Ghassemi M, Andrews DW, Moses AM The Cells Out of Sample (COOS) dataset and benchmarks for measuring out-of-sample generalization of image classifiers Advances in Neural Information Processing Systems 32 (NeurIPS 2019)
NeurIPS link PDF Mirror Book Chapter
Deep Learning Covariate shift Image analysis Subcellular localization
Lu AX, Kraus OZ, Cooper S, Moses AM. Learning unsupervised feature representations for single cell microscopy images with paired cell inpainting. PLoS Comput Biol. 2019 Sep 3;15(9):e1007348.
PLoS Comp. Bio link PDF Mirror PubMed Abstract Article
Deep Learning Self-Supervised Image analysis Subcellular localization
Pritišanac I, Vernon RM, Moses AM, Forman-Kay JD Entropy and Information within Intrinsically Disordered Protein Regions . Entropy 2019 21(7), 662
Entropy link PDF Mirror Review
Information theory Biophysics Intrinsically disordered Evolution


The Moses Lab is affiliated with the departments of Cell and Systems Biology, Computer Science, and Ecology and Evolutionary Biology at the University of Toronto. Our lab is in the Ramsay-Wright Labs (25 Harbord St.), located on the southwest side of the St. George Campus. To contact Alan or other lab members, please visit the People page.