in Genome Biology and Bioinformatics -- CSB 1482
Mondays 11 am – 1 pm
Location: Earth Sciences Centre, Room 3044
and readings for 2018
duplication (Wolfe & Shields Nature 1997)
A general stress response in yeast (Gasch et al. Mol. Biol. Cell.
Sept. 24: Conserved non-coding sequences in vertebrates (Woolfe et al. PloS Biol. 2005)
Finding tissue-specific enhancers (Visel et al. Nature 2009)
Oct. 8: ***No class*** Thanksgiving
proximity determines genetic relatedness of humans (Novembre et al. Nature
22: Widespread bimodality in gene expression (Shalek et al. Nature
29: Genome browsers (Kent et al. Genome Research 2002)
Nov. 5: ***No class*** Reading week
12: Quantifying mRNA expression (Trapnell et al. Nat. Biotech.
Nov. 19: Gene set enrichment analysis (
26: Finding human miRNA targets (Lewis et al. Cell 2005)
Dec. 3: Clustering protein interactions (Bader & Hogue BMC Bioinf. 2003)
Dec. 6: Read mapping (Li & Durbin Genome Res. 2008) ***Earth Sciences 1014***
various papers, students will be assigned to present one of a) context
b) a figure c) a method or c) impact. A final assignment where students
select a paper from the past
5 years and argue that it is "future classic" in genome
biology and bioinformatics.